Collagen Science

collagen science

Scientific References:

  1. Cosgrove, M.C. et al., 2007, Dietary nutrient intakes and skin-ageing appearance among middle-aged American women. American Journal of Clinical Nutrition, 86 (4): 1225-1231
  2. Borumand, M. et al., 2014, Daily consumption of the collagen supplement Pure Gold Collagen® reduces visible signs of ageing, Clinical Interventions in Aging. 9:1747-1758.
  3. Asserin, J. et al., 2015. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Journal of Cosmetic Dermatology, doi: 10.1111/jocd.12174
  4. Benito-Ruiz P. et al. (2009). A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. International Journal of Food Sciences and Nutrition, 60: 99-113
  5. Bruyere O et al. (2012). Effect of collagen hydrolysate in articular pain: A 6-month randomized, double-blind, placebo-controlled study. Complementary Therapies in Medicine, 20: 124-130.
  6. Campos, Mbg, P. M. et al., 2015, An Oral Supplementation Based on Hydrolyzed Collagen and Vitamins Improves Skin Elasticity and Dermis Echogenicity: A Clinical Placebo-Controlled Study. Clinical Pharmacology & Biopharmaceutics, 04(03)
  7. Carrino, DA., Sorrell, JM. and Caplan, AL. Age-related changes in the proteoglycans of human skin. Arch Biochem Biophys. 373(1), 91–101 (2000).
  8. Clark K.L. et al. (2008). A 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Current Medical Research and Opinion, 24(5):1485-96.
  9. Dawley Male Rats. Journal of Food Science, 75(8): H230-H238.
  10. De Almeida et al. (2010). A food supplement of hydrolyzed collagen improves compositional and biodynamic characteristics of vertebrae in ovariectomized rats. Journal of Medicinal Food, 13(6):1385-90.
  11. Guillerminet F et al. (2010). Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice: an in vitro and in vivo study. Bone, 46(3):827-34
  12. Guillerminet F. et al. (2012). Hydrolyzed collagen improves bone status and prevents bone loss in ovariectomized C3H/HeN mice. Osteoporosis International, 23: 1909–1919
  13. Han X et al. (2009). Effects of cod bone gelatin on bone metabolism and bone microarchitecture in ovariectomized rats. Bone, 44: 942-947
  14. Jiang JX. et al. (2013). Peptan collagen peptides for the treatment of knee osteoarthritis: A double-blind, randomized, placebo-controlled study. Agro FOOD Industry Hi-Tech, Vol 25(2):19-23
  15. Kim et al. (2013). Osteogenic activity of collagen peptide via ERK/MAPK pathway mediated boosting of collagen synthesis and its therapeutic efficacy in osteoporotic bone by back-scattered electron imaging and microarchitecture analysis. Molecules, 12;18(12):15474-89
  16. Liang J. (2010). The Protective Effects of Long-Term Oral Administration of Marine Collagen Hydrolysate from Chum Salmon on Collagen Matrix Homeostasis in the Chronological Aged Skin of Sprague
  17. Liang, J. et al., 2010, The Protective Effects of Long-Term Oral Administration of Marine Collagen Hydrolysate from Chum Salmon on Collagen Matrix Homeostasis in the Chronological Aged Skin of Sprague-Dawley Male Rats. Journal of Food Science, 75(8)
  18. Liu J. et al. (2014). Bovine Collagen Peptides Compounds Promote the Proliferation and Differentiation of MC3T3-E1 Pre-Osteoblasts. PLoS One, 13;9(6): e99920.
  19. Matsuda, N. et al., 2006, Effects of Ingestion of Collagen Peptide on Collagen Fibrils and Glycosaminoglycans in the Dermis. Journal of Nutritional Science and Vitaminology, 52(3):211-215
  20. Matsumoto H. et al. (2006). Clinical effects of fish type 1 collagen hydrolysate on skin properties. ITE Letters on Batteries, New Technologies and Medicine, 7 (4): 386-390
  21. Matsumoto, et al., 2006, Clinical effects of fish type I collagen hydrolysate on skin properties. ITE Letters on Batteries, New Technologies and Medicine, 7(4):386-390
  22. Mizuno M. et al. (2001). Osteoblast-related gene expression of bone marrow cells during the osteoblastic differentiation induced by type I collagen. Journal of Biochemistry, 129: 133-138
  23. Morganti et al. (1988). Oral treatment of skin dryness. Cosmetics and Toiletries, 103: 77-80
  24. Moskowitz (2000). Role of collagen hydrolysate in bone and joint disease. Seminars in Arthritis and Rheumatism, 30(2):87-99.
  25. Nomura et al. (2005). Increase in bone mineral density through oral administration of shark gelatin to ovariectomized rats. Nutrition, 21(11-12):1120-6
  26. Oesser, S. et al. (1999). Oral Administration of 14C Labelled Gelatine Hydrolysate Leads to an Accumulation of Radioactivity in Cartilage of Mice (C57/BL). Journal of Nutrition, 129: 1891-1895
  27. Oesser, S. et al. (2003). Stimulation of Type II Collagen Biosynthesis and Secretion in Bovine Chondrocytes Cultured with Degraded Collagen. Cell Tissue Research, 311: 393-399
  28. Ohara H et al. (2009). Improvement in the moisture content of the stratum corneum following 4 weeks of collagen hydrolysate ingestion. Food Science and Technical Research, 56: 137-145.
  29. Ohara H, et al. Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. Journal of Dermatology., 37: 330-338
  30. Ohara, H. et al., 2010, Effects of Pro-Hyp, a Collagen Hydrolysate Derived Peptide, on Hyaluronic Acid Synthesis Using in Vitro Cultured Synovium Cells and Oral Ingestion of Collagen Hydrolysates in a Guinea Pig Model of Osteoarthritis. Bioscience, Biotechnology, and Biochemistry, 74(10):2096-2099
  31. Postlethwaite, A.E. et al. 1978. Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides. Proceedings of the National Academy of Sciences of the United States of America. 75(2): 871-875.
  32. Ragle R.L. et al. (2012). Nutraceuticals in the management of osteoarthritis: a critical review. Drugs Aging, 29(9):717 – 731
  33. Rousselot unpublished data, 2008. The clinical study, Souken, Japan.
  34. Rousselot unpublished data, 2011. Ex vivo study, Bio-EC laboratory, France.
  35. Rousselot unpublished data, 2011. In vitro study, Atlantic Bone Screen, France.
  36. Rousselot unpublished data, 2012. The clinical study, Cosderma, France.
  37. Shigemura, Y. et al., 2009, Effect of Prolyl-hydroxyproline (Pro-Hyp), a Food-Derived Collagen Peptide in Human Blood, on Growth of Fibroblasts from Mouse Skin. Journal of Agricultural and Food Chemistry, 57(2):444- 449
  38. Shuster, S., Black, M. and McVitie, E. The influence of age and sex on skin thickness, skin collagen and density. British Journal of Dermatology 93(6), 639–643 (1975).
  39. Trč T et al. (2011). Efficacy and tolerance of enzymatically hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). International Orthopaedics, 35 (3): 341–348.
  40. Van Vivjen J.P et al. (2012).Symptomatic and chondroprotective treatment with collagen derivatives in osteoarthritis: a systematic review. Osteoarthritis Cartilage, 20(8):809-21.
  41. Watanabe-Kamiyama, M. et al., 2010, Absorption and Effectiveness of Orally Administered Low Molecular Weight Collagen Hydrolysate in Rats. Journal of Agricultural and Food Chemistry, 58(2):835-8411.
  42. Willen, DM., Sorrel, JM., Lekan, CC., Davis, BR. And Caplan, AI. Patterns of Glycosaminoglycan/Proteoglycan Immunostaining in Human Skin During Aging. Journal of Investigative Dermatology 96, 968–974 (1991).
  43. Wu J. et al. (2004). Assessment of the effectiveness of oral administration of collagen peptide on bone metabolism in growing and mature rats. Journal of Bone and Mineral Metabolism, 22(6):547-53.

Collagen science references More studies are available on request.

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