For the “collagen powder”, or more accurately, “Collagen Peptides” to actually work effectively; you need the following characteristics:
There are hundreds of suppliers for collagen peptides popping up across the world, each one offering better collagen than its competitors.
Lots of promises;
and tens more claims and promises.
The best practice is to do some research and select one of the manufacturers with a proven reputation.
Or if you want to buy inexpensive collagen with lots of promises, send a request to the brand for legitimate (Verified) certification for each of their claims.
And very important, it must be certified FREE from;
It is also important to check, if possible if the products were irradiated. This is normally done to extend shelf life after manufacturing. The process is not common for capsule or powdered collagen peptide products but it might be the case for liquid collagen products.
This is one of the main considerations in the manufacturing process.
And then the whole reason for your research, “Does the product work?”.
The only way to determine the efficacy of a product is through studies and human clinical trials.
How well were the collagen peptides absorbed, what is the bio-availability, and have the peptides been used as collagen fibre building blocks? Is there any clinical evidence of increased activity of fibroblast or osteoblast?
Ultimately, have the consumer experienced any improvement in skin, joint or bone condition? Was there any visible change in skin condition or wrinkles?
Consumers read about the benefits of collagen (Collagen peptides) but rarely understand that 90% of the benefits are not visible or you can’t necessarily feel or experience any gratification.
Most of the results take time, it builds up little by little over time. A few months later you stop using the supplement and then you experience the negative effect of using this important supplement.
43 Studies and Scientific evidence > Click Here
It is very important that the collagen you use is both bioavailable and has efficient bioactivity.
Bioavailability in this case refers to the accessibility of the collagen peptide as a nutrient within the powder and the ability of the body to absorb the peptides into the bloodstream.
Bioactivity refers to the ability of a small molecule to modulate a biological function of a target cell and/or tissue. In this case, di-peptides and tri-peptides are specific to humans.
Bioactivity is what makes a nutrient beneficial.
As mentioned above, “Bio-activity is what makes the nutrient beneficial”.
The bioactive peptides of collagen are the Di-peptides and Tri-peptides.
It is therefore very important to use collagen peptide products with a high density of di-peptides and tripeptides for the best value for money and results,
The two most abundant dipeptides in collagen supplements are hydroxyproline-glycine (Hyp-Gly) and proline-hydroxyproline (Pro-Hyp), well-known for their bioactivity.
Evenly important is the easy-to-absorb, tripeptide format Gly-X-Y, where X and Y most commonly include proline, hydroxyproline and alanine.
 Kleinnijenhuis, A.J., 2019. Non-targeted and targeted analysis of collagen hydrolysates during the course of digestion and absorption. Anal Bioanal Chem. 2019 Dec 24. doi: 10.1007/s00216-019-02323-x.
 Ohara, H., et al., 2010. Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. The Journal of Dermatology, 37(4), 330–338. doi: 10.1111/j.1346-8138.2010.00827.x
 Asai, T. T. et al., 2019. Food-Derived Collagen Peptides, Prolyl-Hydroxyproline (Pro-Hyp), and Hydroxyprolyl-Glycine (Hyp-Gly) Enhance Growth of Primary Cultured Mouse Skin Fibroblast Using Fetal Bovine Serum Free from Hydroxyprolyl Peptide. International Journal of Molecular Sciences, 21(1), 229. doi: 10.3390/ijms21010229