Evidence Based Science

Scientific References:

References:

1. Cosgrove, M.C. et al., 2007, Dietary nutrient intakes and skin-aging appearance among middle-aged American women. American Journal of Clinical Nutrition, 86 (4): 1225-1231
2. Borumand, M. et al., 2014, Daily consumption of the collagen supplement Pure Gold Collagen® reduces visible signs of aging, Clinical Interventions in Aging. 9:1747-1758.
3. Asserin, J. et al., 2015. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Journal of Cosmetic Dermatology, doi: 10.1111/jocd.12174

The studies have been performed by independent institutes commissioned by

4. Postlethwaite, A.E. et al. 1978. Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides. Proceedings of the National Academy of Sciences of the United States of America. 75(2): 871-875.
5. Shigemura Y, et al. 2009. Effect of prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin. Journal of Agricultural and Food Chemistry 57(2), 444-449
6. Ohara H, et al. Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. Journal of Dermatology., 37: 330-338
7. Postlethwaite, A. E. et al., 1978, Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides. Proceedings of the National Academy of Sciences, 75(2):871-875
8. Shigemura, Y. et al., 2009, Effect of Prolyl-hydroxyproline (Pro-Hyp), a Food-Derived Collagen Peptide in Human Blood, on Growth of Fibroblasts from Mouse Skin. Journal of Agricultural and Food Chemistry, 57(2):444- 449
9. Ohara, H. et al., 2010, Effects of Pro-Hyp, a Collagen Hydrolysate Derived Peptide, on Hyaluronic Acid Synthesis Using in Vitro Cultured Synovium Cells and Oral Ingestion of Collagen Hydrolysates in a Guinea Pig Model of Osteoarthritis. Bioscience, Biotechnology, and Biochemistry, 74(10):2096-2099
10. Campos, Mbg, P. M. et al., 2015, An Oral Supplementation Based on Hydrolyzed Collagen and Vitamins Improves Skin Elasticity and Dermis Echogenicity: A Clinical Placebo-Controlled Study. Clinical Pharmacology & Biopharmaceutics, 04(03)
11. Matsumoto, et al., 2006, Clinical effects of fish type I collagen hydrolysate on skin properties. ITE Letters on Batteries, New Technologies and Medicine, 7(4):386-390
12. Matsuda, N. et al., 2006, Effects of Ingestion of Collagen Peptide on Collagen Fibrils and Glycosaminoglycans in the Dermis. Journal of Nutritional Science and Vitaminology, 52(3):211-215
13. Liang, J. et al., 2010, The Protective Effects of Long-Term Oral Administration of Marine Collagen Hydrolysate from Chum Salmon on Collagen Matrix Homeostasis in the Chronological Aged Skin of Sprague-Dawley Male Rats. Journal of Food Science, 75(8)
14. Watanabe-Kamiyama, M. et al., 2010, Absorption and Effectiveness of Orally Administered Low Molecular Weight Collagen Hydrolysate in Rats. Journal of Agricultural and Food Chemistry, 58(2):835-8411.
15. Carrino, DA., Sorrell, JM. and Caplan, AL. Age-related changes in the proteoglycans of human skin. Arch Biochem Biophys. 373(1), 91–101 (2000).
16. Willen, DM., Sorrel, JM., Lekan, CC., Davis, BR. And Caplan, AI. Patterns of Glycosaminoglycan/Proteoglycan Immunostaining in Human Skin During Aging. Journal of Investigative Dermatology 96, 968–974 (1991).
17. Shuster, S., Black, M. and McVitie, E. The influence of age and sex on skin thickness, skin collagen and density. British Journal of Dermatology 93(6), 639–643 (1975).

More studies are available on request.