- Cosgrove, M.C. et al., 2007, Dietary nutrient intakes and skin-aging appearance among middle-aged American women. American Journal of Clinical Nutrition, 86 (4): 1225-1231
- Borumand, M. et al., 2014, Daily consumption of the collagen supplement Pure Gold Collagen® reduces visible signs of aging, Clinical Interventions in Aging. 9:1747-1758.
- Asserin, J. et al., 2015. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Journal of Cosmetic Dermatology, doi: 10.1111/jocd.12174
The studies have been performed by independent institutes commissioned by
- Postlethwaite, A.E. et al. 1978. Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides. Proceedings of the National Academy of Sciences of the United States of America. 75(2): 871-875.
- Shigemura Y, et al. 2009. Effect of prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin. Journal of Agricultural and Food Chemistry 57(2), 444-449
- Ohara H, et al. Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. Journal of Dermatology., 37: 330-338
- Postlethwaite, A. E. et al., 1978, Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides. Proceedings of the National Academy of Sciences, 75(2):871-875
- Shigemura, Y. et al., 2009, Effect of Prolyl-hydroxyproline (Pro-Hyp), a Food-Derived Collagen Peptide in Human Blood, on Growth of Fibroblasts from Mouse Skin. Journal of Agricultural and Food Chemistry, 57(2):444- 449
- Ohara, H. et al., 2010, Effects of Pro-Hyp, a Collagen Hydrolysate Derived Peptide, on Hyaluronic Acid Synthesis Using in Vitro Cultured Synovium Cells and Oral Ingestion of Collagen Hydrolysates in a Guinea Pig Model of Osteoarthritis. Bioscience, Biotechnology, and Biochemistry, 74(10):2096-2099
- Campos, Mbg, P. M. et al., 2015, An Oral Supplementation Based on Hydrolyzed Collagen and Vitamins Improves Skin Elasticity and Dermis Echogenicity: A Clinical Placebo-Controlled Study. Clinical Pharmacology & Biopharmaceutics, 04(03)
- Matsumoto, et al., 2006, Clinical effects of fish type I collagen hydrolysate on skin properties. ITE Letters on Batteries, New Technologies and Medicine, 7(4):386-390
- Matsuda, N. et al., 2006, Effects of Ingestion of Collagen Peptide on Collagen Fibrils and Glycosaminoglycans in the Dermis. Journal of Nutritional Science and Vitaminology, 52(3):211-215
- Liang, J. et al., 2010, The Protective Effects of Long-Term Oral Administration of Marine Collagen Hydrolysate from Chum Salmon on Collagen Matrix Homeostasis in the Chronological Aged Skin of Sprague-Dawley Male Rats. Journal of Food Science, 75(8)
- Watanabe-Kamiyama, M. et al., 2010, Absorption and Effectiveness of Orally Administered Low Molecular Weight Collagen Hydrolysate in Rats. Journal of Agricultural and Food Chemistry, 58(2):835-8411.
- Carrino, DA., Sorrell, JM. and Caplan, AL. Age-related changes in the proteoglycans of human skin. Arch Biochem Biophys. 373(1), 91–101 (2000).
- Willen, DM., Sorrel, JM., Lekan, CC., Davis, BR. And Caplan, AI. Patterns of Glycosaminoglycan/Proteoglycan Immunostaining in Human Skin During Aging. Journal of Investigative Dermatology 96, 968–974 (1991).
- Shuster, S., Black, M. and McVitie, E. The influence of age and sex on skin thickness, skin collagen and density. British Journal of Dermatology 93(6), 639–643 (1975).
More studies are available on request.